Article
Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype.
Blood - 7 Nov 2013
Migliorini Gabriele, Fiege Bettina, Hosking Fay J, Ma Yussanne, Kumar Rajiv, Sherborne Amy L, da Silva Filho Miguel Inacio, Vijayakrishnan Jayaram, Koehler Rolf, Thomsen Hauke, Irving Julie A, Allan James M, Lightfoot Tracy, Roman Eve, Kinsey Sally E, Sheridan Eamonn, Thompson Pamela, Hoffmann Per, Nöthen Markus M, Mühleisen Thomas W, Eisele Lewin, Zimmermann Martin, Bartram Claus R, Schrappe Martin, Greaves Mel, Stanulla Martin, Hemminki Kari, Houlston Richard S
Abstract excerpt
Acute lymphoblastic leukemia (ALL) is the major pediatric cancer diagnosed in economically developed countries with B-cell precursor (BCP)-ALL, accounting for approximately 70% of ALL. Recent genome-wide association studies (GWAS) have provided the first unambiguous evidence for common inherited susceptibility to BCP-ALL, identifying susceptibility loci at 7p12.2, 9p21.3, 10q21.2, and 14q11.2. To identify...
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