Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.

Nature - 12 Apr 2007

Mullighan Charles G, Goorha Salil, Radtke Ina, Miller Christopher B, Coustan-Smith Elaine, Dalton James D, Girtman Kevin, Mathew Susan, Ma Jing, Pounds Stanley B, Su Xiaoping, Pui Ching-Hon, Relling Mary V, Evans William E, Shurtleff Sheila A, Downing James R

Abstract excerpt

Chromosomal aberrations are a hallmark of acute lymphoblastic leukaemia (ALL) but alone fail to induce leukaemia. To identify cooperating oncogenic lesions, we performed a genome-wide analysis of leukaemic cells from 242 paediatric ALL patients using high-resolution, single-nucleotide polymorphis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PAX5 Transcription Factor

Share to Point Mutation

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Sequence Deletion

Share to Trans-Activators

Share to Translocation, Genetic

Source

Identifiers

PMID: 17344859
DOI: 10.1038/nature05690

Genes

PAX5
EBF1
IKZF1
IKZF3
TCF3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17344859-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.PMID 17344859Read ↗

Genomics in acute lymphoblastic leukaemia: insights and treatment implications.Semantic proximity Read ↗

Genetic defects in hematopoietic transcription factors and predisposition to acute lymphoblastic leukemiaSemantic proximity Read ↗

Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemiaSemantic proximity Read ↗

Integrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trialSemantic proximity Read ↗

Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease.Semantic proximity Read ↗

Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemiaSemantic proximity Read ↗

Molecular genetics of B-precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

PAX5 alterations in B-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

The genomic landscape of pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Advances in the Biology of Acute Lymphoblastic Leukemia—From Genomics to the ClinicSemantic proximity Read ↗

Genetic abnormalities associated with acute lymphoblastic leukemia.Semantic proximity Read ↗

New Challenges in Targeting Signaling Pathways in Acute Lymphoblastic Leukemia by NGS Approaches: An UpdateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.