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Genetic defects in hematopoietic transcription factors and predisposition to acute lymphoblastic leukemia

16 Jul 2019

Abstract excerpt

Recent genome-wide studies have revealed a plethora of germline variants that significantly influence the susceptibility to acute lymphoblastic leukemia (ALL), thus providing compelling evidence for genetic inheritance of this blood cancer. In particular, hematopoietic transcription factors (eg, ETV6, PAX5, IKZF1) are most frequently implicated in familial ALL, and germline variants in these genes confer strong...

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PMID: 31311817
DOI: 10.1182/blood.2018852400

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