Article
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
Nature communications - 9 Apr 2018
Vijayakrishnan Jayaram, Studd James, Broderick Peter, Kinnersley Ben, Holroyd Amy, Law Philip J, Kumar Rajiv, Allan James M, Harrison Christine J, Moorman Anthony V, Vora Ajay, Roman Eve, Rachakonda Sivaramakrishna, Kinsey Sally E, Sheridan Eamonn, Thompson Pamela D, Irving Julie A, Koehler Rolf, Hoffmann Per, Nöthen Markus M, Heilmann-Heimbach Stefanie, Jöckel Karl-Heinz, Easton Douglas F, Pharaoh Paul D P, Dunning Alison M, Peto Julian, Canzian Frederico, Swerdlow Anthony, Eeles Rosalind A, Kote-Jarai ZSofia, Muir Kenneth, Pashayan Nora, Greaves Mel, Zimmerman Martin, Bartram Claus R, Schrappe Martin, Stanulla Martin, Hemminki Kari, Houlston Richard S
Abstract excerpt
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio...
Topics
Join the communities discussing this publication.