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Genetic subtypes of B-cell acute lymphoblastic leukemia in adults

30 Dec 2024

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ABSTRACT: B-cell acute lymphoblastic leukemia (B-ALL) is a rare malignancy in adults, with outcomes remaining poor, especially compared with children. Over the past 2 decades, extensive whole-genome studies have identified numerous genetic alterations driving leukemia, leading to the recognition of >20 distinct subtypes that are closely associated with treatment response and prognosis. In pediatric B-ALL, large...

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PMID: 39786374
DOI: 10.1182/blood.2023022919

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