Article
Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci.
Nature communications - 22 Oct 2025
Im Cindy, Raduski Andrew R, Mills Lauren J, Bhattarai Kashi Raj, Mobley Robert J, Barnett Kelly R, Lu Zhanni, Liao Kenneth, Anderson Nathan, Johnson Rebecca A, Langer Erica, Hooten Anthony J, Seif Alix E, Bernt Kathrin M, Tsang Matthew, Mamou Brandon A, Gil-de-Gómez Luis, Wolfson Julie A, Friedman Danielle N, Shukla Neerav, Klesse Laura J, Marcotte Erin L, Ji Lingyun, Dang Alice, Luo Minjie, Zhong Yiming, Langie Jalen, Chiang Charleston W K, de Smith Adam, Wiemels Joseph L, DeWan Andrew, Ma Xiaomei, Metayer Catherine, Wang Zhaoming, Nelson Heather H, Pankratz Nathan, Yang Tianzhong, Basu Saonli, Turcotte Lucie M, Yang Jun J, Savic Daniel, Scheurer Michael E, Spector Logan G
Abstract excerpt
B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric malignancy. Given racial/ethnic differences in incidence and outcomes, B-ALL genome-wide association studies among children of African ancestry are needed. Leveraging multi-institutional datasets with 840 African American children with B-ALL and 3360 controls, nine loci achieved genome-wide significance (P < 5 × 10-8) after meta-analysis....
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