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Epigenetic Modification of Cytosines in Hematopoietic Differentiation and Malignant Transformation

15 Jan 2023

Abstract excerpt

The mammalian DNA methylation landscape is established and maintained by the combined activities of the two key epigenetic modifiers, DNA methyltransferases (DNMT) and Ten-eleven-translocation (TET) enzymes. Once DNMTs produce 5-methylcytosine (5mC), TET proteins fine-tune the DNA methylation status by consecutively oxidizing 5mC to 5-hydroxymethylcytosine (5hmC) and further oxidized derivatives. The 5mC and...

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PMID: 36675240
DOI: 10.3390/ijms24021727

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