Article
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.
Science (New York, N.Y.) - 13 May 2016
Lu Chao, Jain Siddhant U, Hoelper Dominik, Bechet Denise, Molden Rosalynn C, Ran Leili, Murphy Devan, Venneti Sriram, Hameed Meera, Pawel Bruce R, Wunder Jay S, Dickson Brendan C, Lundgren Stefan M, Jani Krupa S, De Jay Nicolas, Papillon-Cavanagh Simon, Andrulis Irene L, Sawyer Sarah L, Grynspan David, Turcotte Robert E, Nadaf Javad, Fahiminiyah Somayyeh, Muir Tom W, Majewski Jacek, Thompson Craig B, Chi Ping, Garcia Benjamin A, Allis C David, Jabado Nada, Lewis Peter W
Abstract excerpt
Several types of pediatric cancers reportedly contain high-frequency missense mutations in histone H3, yet the underlying oncogenic mechanism remains poorly characterized. Here we report that the H3 lysine 36-to-methionine (H3K36M) mutation impairs the differentiation of mesenchymal progenitor cells and generates undifferentiated sarcoma in vivo. H3K36M mutant nucleosomes inhibit the enzymatic activities of...
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