Article
Remethylation of Dnmt3a-/- hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing.
Proceedings of the National Academy of Sciences of the United States of America - 11 Feb 2020
Ketkar Shamika, Verdoni Angela M, Smith Amanda M, Bangert Celia V, Leight Elizabeth R, Chen David Y, Brune Meryl K, Helton Nichole M, Hoock Mieke, George Daniel R, Fronick Catrina, Fulton Robert S, Ramakrishnan Sai Mukund, Chang Gue Su, Petti Allegra A, Spencer David H, Miller Christopher A, Ley Timothy J
Abstract excerpt
Mutations in the DNA methyltransferase 3A (DNMT3A) gene are the most common cause of age-related clonal hematopoiesis (ARCH) in older individuals, and are among the most common initiating events for acute myeloid leukemia (AML). The most frequent DNMT3A mutation in AML patients (R882H) encodes a dominant-negative protein that reduces methyltransferase activity by ∼80% in cells with heterozygous mutations, causing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.