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Article

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice.

Blood - 24 May 2018

Dahlin Joakim S, Hamey Fiona K, Pijuan-Sala Blanca, Shepherd Mairi, Lau Winnie W Y, Nestorowa Sonia, Weinreb Caleb, Wolock Samuel, Hannah Rebecca, Diamanti Evangelia, Kent David G, Göttgens Berthold, Wilson Nicola K

Abstract excerpt

Hematopoietic stem and progenitor cells (HSPCs) maintain the adult blood system, and their dysregulation causes a multitude of diseases. However, the differentiation journeys toward specific hematopoietic lineages remain ill defined, and system-wide disease interpretation remains challenging. Here, we have profiled 44 802 mouse bone marrow HSPCs using single-cell RNA sequencing to provide a comprehensive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29588278
DOI: 10.1182/blood-2017-12-821413
PMCID: PMC5969381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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