Leveraging dominant-negative histone H3 K-to-M mutations to study chromatin during differentiation and development.

Abstract excerpt

Histone modifications are associated with regulation of gene expression that controls a vast array of biological processes. Often, these associations are drawn by correlating the genomic location of a particular histone modification with gene expression or phenotype; however, establishing a causal relationship between histone marks and biological processes remains challenging. Consequently, there is a strong need...

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