Article

The H3K4 methyltransferase KMT2D is an essential cofactor for GATA1 at erythroid gene enhancers

2025-10-22

Abstract excerpt

<title>Abstract</title> <p> Gene expression during cellular differentiation is coordinated by combinatorial interactions between transcription factors (TFs) and cofactors at promoters and enhancers. The “master TF” GATA1 coordinates gene transcription in a subset of hematopoietic lineages, including erythroid, megakaryocytic, mast, and eosinophil, while repressing the development of other blood lineages. However...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 606509cd-0536-558f-987f-6107e1aa55b8
DOI: 10.21203/rs.3.rs-7853319/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The H3K4 methyltransferase KMT2D is an essential cofactor for GATA1 at erythroid gene enhancersDOI 10.21203/rs.3.rs-7853319/v1Read

Characterizing the molecular impact of<i>KMT2D</i>variants on the epigenetic and transcriptional landscapes in Kabuki SyndromeSemantic proximity Read

Characterizing the molecular impact of KMT2D variants on the epigenetic and transcriptional landscapes in Kabuki syndrome.Semantic proximity Read

N <sup>6</sup> -methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesisSemantic proximity Read

Role of the pioneer transcription factor GATA2 in health and disease.Semantic proximity Read

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cellsSemantic proximity Read

Gata2a maintains <i>cebpa</i> and <i>npm1a</i> in haematopoietic stem cells to sustain lineage differentiation and genome stabilitySemantic proximity Read

Histone H3 lysine 4 methyltransferase KMT2D.Semantic proximity Read

Long noncoding RNA GATA2AS influences human erythropoiesis by transcription factor and chromatin landscape modulationSemantic proximity Read

Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo.Semantic proximity Read

GATA2 haploinsufficiency causes an epigenetic feedback mechanism resulting in myeloid and erythroid dysplasiSemantic proximity Read

Epigenetic Regulation of Erythropoiesis: From Developmental Programs to Therapeutic TargetsSemantic proximity Read

Master Transcription Factors Regulate the DNA Methylation Landscape During Hepatocyte DifferentiationSemantic proximity Read