Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic identification of mutations and copy number alterations associated with cancer patient prognosis.

eLife - 11 Dec 2018

Smith Joan C, Sheltzer Jason M

Abstract excerpt

Successful treatment decisions in cancer depend on the accurate assessment of patient risk. To improve our understanding of the molecular alterations that underlie deadly malignancies, we analyzed the genomic profiles of 17,879 tumors from patients with known outcomes. We find that mutations in almost all cancer driver genes contain remarkably little information on patient prognosis. However, CNAs in these same...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Antineoplastic Agents
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Neoplasm Proteins

Share to Oncogenes

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 30526857
DOI: 10.7554/eLife.39217
PMCID: PMC6289580

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic identification of mutations and copy number alterations associated with cancer patient prognosis.PMID 30526857Read ↗

Copy Number Alteration Signatures As Biomarkers in Cancer: A ReviewSemantic proximity Read ↗

An integrated analysis of the epigenetic, genetic, and transcriptional patterns associated with outcome across cancer typesSemantic proximity Read ↗

Signatures of copy number alterations in human cancer.Semantic proximity Read ↗

The repertoire of copy number alteration signatures in human cancerSemantic proximity Read ↗

The repertoire of copy number alteration signatures in human cancer.Semantic proximity Read ↗

Signatures of copy number alterations in human cancerSemantic proximity Read ↗

Assessing the clinical utility of cancer genomic and proteomic data across tumor types.Semantic proximity Read ↗

Gene mutant dosage determines prognosis and metastatic tropism in 60,000 clinical cancer samplesSemantic proximity Read ↗

Optimizing cancer immunotherapy response prediction by tumor aneuploidy score and fraction of copy number alterationsSemantic proximity Read ↗

Consensus Copy-Number Alteration Signatures from Clinical Panels Enable Pan-Cancer Risk Stratification and Therapy Response Association.Semantic proximity Read ↗

Candidate targets of copy number deletion events across 17 cancer typesSemantic proximity Read ↗

Gene mutant dosage is associated with prognosis and metastatic tropism in 60,000 clinical cancer samples.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.