Gene mutant dosage is associated with prognosis and metastatic tropism in 60,000 clinical cancer samples.

Abstract excerpt

The interplay between somatic mutations and copy number alterations influences tumor evolution and prognosis. These alterations are often treated independently, overlooking gene mutant dosage (GMD)-a key property of their interaction. Here we develop a computational framework that infers mutation copy number and multiplicity from targeted sequencing panels without requiring matched normal samples. We derive GMD...

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