Article

The repertoire of copy number alteration signatures in human cancer

2022-11-16

Abstract excerpt

Copy number alterations (CNAs) are a predominant source of genetic alterations in human cancer and play an important role in cancer progression. However comprehensive understanding of the mutational processes and signatures of CNA is still lacking. Here we developed a mechanism-agnostic method to categorize CNA based on various fragment properties, which reflect the consequences of mutagenic processes and can be e...

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Literature Corpus work: 99ee456c-dcc0-5d2d-b0bb-04392d889ec7
DOI: 10.1101/2022.11.14.516412

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