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Copy Number Alteration Signatures As Biomarkers in Cancer: A Review

23 Feb 2022

Abstract excerpt

Within certain cancers, extensive copy number alterations (CNAs) contribute to a complex and heterogenic genomic profile. This makes it difficult to understand and unravel the distinct molecular dynamics shaping the disease while preventing clinically effective patient stratification. CNA signature analysis represents a novel genomic stratification tool for probing this complexity, offering an intricate framework...

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Identifiers

PMID: 35195030
DOI: 10.2217/bmm-2021-0476

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