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Article

The repertoire of copy number alteration signatures in human cancer.

Briefings in bioinformatics - 19 Mar 2023

Tao Ziyu, Wang Shixiang, Wu Chenxu, Wu Tao, Zhao Xiangyu, Ning Wei, Wang Guangshuai, Wang Jinyu, Chen Jing, Diao Kaixuan, Chen Fuxiang, Liu Xue-Song

Abstract excerpt

Copy number alterations (CNAs) are a predominant source of genetic alterations in human cancer and play an important role in cancer progression. However comprehensive understanding of the mutational processes and signatures of CNA is still lacking. Here we developed a mechanism-agnostic method to categorize CNA based on various fragment properties, which reflect the consequences of mutagenic processes and can be...

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Identifiers

PMID: 36806386
DOI: 10.1093/bib/bbad053
PMCID: PMC10025440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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