Article
Signatures of copy number alterations in human cancer.
Nature - 1 Jun 2022
Steele Christopher D, Abbasi Ammal, Islam S M Ashiqul, Bowes Amy L, Khandekar Azhar, Haase Kerstin, Hames-Fathi Shadi, Ajayi Dolapo, Verfaillie Annelien, Dhami Pawan, McLatchie Alex, Lechner Matt, Light Nicholas, Shlien Adam, Malkin David, Feber Andrew, Proszek Paula, Lesluyes Tom, Mertens Fredrik, Flanagan Adrienne M, Tarabichi Maxime, Van Loo Peter, Alexandrov Ludmil B, Pillay Nischalan
Abstract excerpt
Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-related processes of replication stress, mitotic errors, spindle multipolarity and breakage-fusion-bridge cycles, among others, which may lead to chromosomal instability and aneuploidy1,2. These copy number alterations contribute to cancer initiation, progression and therapeutic resistance3-5. Here we present a conceptual...
Topics
- Aneuploidy
- Chromothripsis
- DNA Copy Number Variations
- DNA Mutational Analysis
- Haploidy
- Homologous Recombination
- Humans
- Loss of Heterozygosity
- Mutation