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Article

Consensus Copy-Number Alteration Signatures from Clinical Panels Enable Pan-Cancer Risk Stratification and Therapy Response Association.

International journal of molecular sciences - 12 Feb 2026

Yaacov Adar

Abstract excerpt

Somatic copy-number alterations (CNAs) are pervasive in cancer, but routine targeted panels yield sparse CNA readouts unsuited for CNA signature analysis. We built a consensus framework that integrates four deconvolution algorithms to extract CNA signatures from panel data. Analysis of 24,870 tumors sequenced using MSK-IMPACT identified five reproducible signatures (CON1-CON5). CON5 mirrored near-diploid...

Topics

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Algorithms
Biomarkers, Tumor
DNA Copy Number Variations
GATA3 gene
IMPACT gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 41751900
DOI: 10.3390/ijms27041764
PMCID: PMC12940284

Genes

GATA3
IMPACT
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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