Article

Gene mutant dosage determines prognosis and metastatic tropism in 60,000 clinical cancer samples

2024-05-13

Abstract excerpt

The intricate interplay between somatic mutations and copy number alterations critically influences tumour evolution and patient prognosis. However, traditional genomic analyses often treat these alterations independently, overlooking gene mutant dosage — a key emergent property of their interaction. Here, we develop an innovative computational framework that infers allele-specific copy number alterations directly...

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Identifiers and source

Literature Corpus work: 2601dc8f-1ce1-546b-bb08-42b61947d032
DOI: 10.1101/2024.05.13.24307238

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