Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry.

doi:10.1002/alz.13880

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Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2024

Ray Nicholas R, Kunkle Brian W, Hamilton-Nelson Kara, Kurup Jiji T, Rajabli Farid, Qiao Min, Vardarajan Badri N, Cosacak Mehmet I, Kizil Caghan, Jean-Francois Melissa, Cuccaro Michael, Reyes-Dumeyer Dolly, Cantwell Laura, Kuzma Amanda, Vance Jeffery M, Gao Sujuan, Hendrie Hugh C, Baiyewu Olusegun, Ogunniyi Adesola, Akinyemi Rufus O, Lee Wan-Ping, Martin Eden R, Wang Li-San, Beecham Gary W, Bush William S, Xu Wanying, Jin Fulai, Wang Liyong, Farrer Lindsay A, Haines Jonathan L, Byrd Goldie S, Schellenberg Gerard D, Mayeux Richard, Pericak-Vance Margaret A, Reitz Christiane

Abstract excerpt

INTRODUCTION: Despite a two-fold risk, individuals of African ancestry have been underrepresented in Alzheimer's disease (AD) genomics efforts. METHODS: Genome-wide association studies (GWAS) of 2,903 AD cases and 6,265 controls of African ancestry. Within-dataset results were meta-analyzed, followed by functional genomics analyses. RESULTS: A novel AD-risk locus was identified in MPDZ on chromosome (chr) 9p23...

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PMID: 38958117
DOI: 10.1002/alz.13880
PMCID: PMC11350055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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