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African origin haplotype protective for Alzheimer’s disease in <i>APOE</i> ε4 carriers: exploring potential mechanisms

2024-10-27

Abstract excerpt

APOE ε4 is the strongest genetic risk factor for Alzheimer’s disease (AD) with approximately 50% of AD patients carrying at least one APOE ε4 allele. Our group identified a protective interaction between APOE ε4 with the African-specific A allele of rs10423769, which reduces the AD risk effect of APOE ε4 homozygotes by approximately 75%. The protective variant lies 2Mb from APOE in a region of segmental duplic...

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Literature Corpus work: b7a90ab8-7be4-5167-8e3f-028881b41791
DOI: 10.1101/2024.10.24.619909

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