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Article

Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer.

Nature medicine - 1 Sept 2018

Patten Darren K, Corleone Giacomo, Győrffy Balázs, Perone Ylenia, Slaven Neil, Barozzi Iros, Erdős Edina, Saiakhova Alina, Goddard Kate, Vingiani Andrea, Shousha Sami, Pongor Lőrinc Sándor, Hadjiminas Dimitri J, Schiavon Gaia, Barry Peter, Palmieri Carlo, Coombes Raul C, Scacheri Peter, Pruneri Giancarlo, Magnani Luca

Abstract excerpt

The degree of intrinsic and interpatient phenotypic heterogeneity and its role in tumor evolution is poorly understood. Phenotypic drifts can be transmitted via inheritable transcriptional programs. Cell-type specific transcription is maintained through the activation of epigenetically defined regulatory regions including promoters and enhancers. Here we have annotated the epigenome of 47 primary and metastatic...

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Identifiers

PMID: 30038216
DOI: 10.1038/s41591-018-0091-x
PMCID: PMC6130800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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