Article
Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions.
Genome research - 15 May 2024
Joosten Stacey E P, Gregoricchio Sebastian, Stelloo Suzan, Yapıcı Elif, Huang Chia-Chi Flora, Yavuz Kerim, Donaldson Collier Maria, Morova Tunç, Altintaş Umut Berkay, Kim Yongsoo, Canisius Sander, Moelans Cathy B, van Diest Paul J, Korkmaz Gozde, Lack Nathan A, Vermeulen Michiel, Linn Sabine C, Zwart Wilbert
Abstract excerpt
Estrogen Receptor 1 (ESR1; also known as ERα, encoded by ESR1 gene) is the main driver and prime drug target in luminal breast cancer. ESR1 chromatin binding is extensively studied in cell lines and a limited number of human tumors, using consensi of peaks shared among samples. However, little is known about inter-tumor heterogeneity of ESR1 chromatin action, along with its biological implications. Here, we use a...
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