Article

Genetic and epigenetic driven variation in regulatory regions activity contribute to adaptation and evolution under endocrine treatment

2022-03-30

Abstract excerpt

<title>Abstract</title> <p>Comprehensive profiling of hormone-dependent breast cancer (HDBC) has identified hundreds of protein-coding alterations contributing to cancer initiation1,2, but only a handful have been linked to endocrine therapy resistance, potentially contributing to 40% of relapses1,3–9. If other mechanisms underlie the evolution of HDBC under adjuvant therapy is currently unknown. In this work, we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 409c13d8-4177-5bdb-b825-0c920349855f
DOI: 10.21203/rs.3.rs-1432636/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic and epigenetic driven variation in regulatory regions activity contribute to adaptation and evolution under endocrine treatmentDOI 10.21203/rs.3.rs-1432636/v1Read

Genetic and epigenetic driven variation in regulatory regions activity contribute to adaptation and evolution under endocrine treatmentSemantic proximity Read

Deciphering Mutational Signature Dynamics in Hormone-Sensitive Breast Cancer During Treatment Adaptation.Semantic proximity Read

Enhancers mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancerSemantic proximity Read

The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.Semantic proximity Read

Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer.Semantic proximity Read

Endocrine therapy-specific lineage and partial epithelial-mesenchymal reprogramming defines divergent resistant cell-states in ER+ breast cancerSemantic proximity Read

Complex rearrangements fuel ER+ and HER2+ breast tumoursSemantic proximity Read

Enhancer plasticity in endometrial tumorigenesis demarcates non-coding somatic mutations and 3D-genome alterations boosting the oncogenic driver ESR1Semantic proximity Read

Emerging Role of Epigenetic Modifiers in Breast Cancer Pathogenesis and Therapeutic ResponseSemantic proximity Read

Epigenomic and genomic dissection of oestrogen receptor-positive breast cancerSemantic proximity Read

Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations.Semantic proximity Read

A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers.Semantic proximity Read