Article

Breast cancer risk SNPs converge on estrogen receptor binding sites commonly shared between breast tumors to locally alter estrogen signalling output

2023-11-02

Abstract excerpt

<h4>ABSTRACT</h4> Estrogen Receptor alpha (ERα) is the main driver and prime drug target in luminal breast. ERα chromatin binding is extensively studied in cell lines and a limited number of human tumors, using consensi of peaks shared among samples. However, little is known about inter-tumor heterogeneity of ERα chromatin action, along with its biological implications. Here, we use a large set of ERα ChIP-seq da...

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Literature Corpus work: 21425bf6-613c-5de7-8189-39c478277e06
DOI: 10.1101/2023.10.30.564691

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