Article

Systematic identification of chromatin organizers as tuners of intratumoral heterogeneity

2026-04-22

Abstract excerpt

Intratumoral transcriptional heterogeneity (ITH) enables tumor cells to explore diverse phenotypic states, fueling therapeutic resistance and metastatic progression. Yet systematic approaches for identifying non-genetic regulators of this phenotype have been lacking. Here, we develop a multi-scale screening framework that integrates bulk patient transcriptomics, functional in vivo genetic screening, and single-ce...

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Literature Corpus work: aeeafbe1-5776-5ac9-b301-83efb48bf34e
DOI: 10.64898/2026.04.18.719392

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