Article

Identification and characterization of a proliferative cell population in estrogen receptor-positive metastatic breast cancer through spatial and single-cell transcriptomics

2023-02-03

Abstract excerpt

<h4>Background</h4> Intratumor heterogeneity is a hallmark of most solid tumors, including breast cancers. We applied spatial transcriptomics and single-cell RNA-sequencing technologies to profile spatially resolved cell populations within estrogen receptor-positive (ER + ) metastatic breast cancers and elucidate their importance in estrogen-dependent tumor growth. <h4>Methods</h4> Spatial transcriptomics and...

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Literature Corpus work: 54f75da9-4944-55ef-8d1d-987ed939dace
DOI: 10.1101/2023.01.31.526403

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