Article

Enhancer plasticity in endometrial tumorigenesis demarcates non-coding somatic mutations and 3D-genome alterations boosting the oncogenic driver ESR1

2023-07-27

Abstract excerpt

<h4>ABSTRACT</h4> The incidence and mortality of Endometrial Cancer (EC) is on the rise. 85% of ECs depend on Estrogen Receptor alpha (ERα) for proliferation, but little is known about its transcriptional regulation in these tumors. We generated epigenomics, transcriptomics and Hi-C datastreams in healthy and tumor endometrial tissues, identifying robust ERα reprogramming and profound alterations in 3D genome org...

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Literature Corpus work: 3074b634-df31-5ff8-a3d1-2edcfdb18eed
DOI: 10.1101/2023.07.25.550368

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