Article

Enhancers mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer

2017-09-26

Abstract excerpt

The degree of intrinsic and interpatient phenotypic heterogeneity and its role in tumour evolution is poorly understood. Phenotypic divergence can be achieved via the inheritance of alternative transcriptional programs 1,2 . Cell-type specific transcription is maintained through the activation of epigenetically-defined regulatory regions including promoters and enhancers 1,3,4 . In this work, we annotated the ep...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6cb354e3-a0be-5ee0-8347-b2ccac56198f
DOI: 10.1101/193771

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enhancers mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancerDOI 10.1101/193771Read

Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer.Semantic proximity Read

Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions.Semantic proximity Read

Genetic and epigenetic driven variation in regulatory regions activity contribute to adaptation and evolution under endocrine treatmentSemantic proximity Read

Breast cancer risk SNPs converge on estrogen receptor binding sites commonly shared between breast tumors to locally alter estrogen signalling outputSemantic proximity Read

Genetic and epigenetic driven variation in regulatory regions activity contribute to adaptation and evolution under endocrine treatmentSemantic proximity Read

GRHL2 motif is associated with intratumor heterogeneity of cis-regulatory elements in luminal breast cancerSemantic proximity Read

Clonal lineage tracing and parallel multiomics profiling reveal transcriptional diversification induced by ARID1A deficiencySemantic proximity Read

Single-Cell Transcriptional and Epigenetic Profiles of Male Breast Cancer Nominate Salient Cancer-Specific EnhancersSemantic proximity Read

Chromatin Patterns Distinguish Breast Tumor Subtypes and Disease Progression in Association with <i>ANP32E</i> levelsSemantic proximity Read

Enhancer plasticity in endometrial tumorigenesis demarcates non-coding somatic mutations and 3D-genome alterations boosting the oncogenic driver ESR1Semantic proximity Read

Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations.Semantic proximity Read

Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast CancerSemantic proximity Read