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Clonal lineage tracing and parallel multiomics profiling reveal transcriptional diversification induced by ARID1A deficiency

2025-05-28

Abstract excerpt

Phenotypic heterogeneity among genetically identical cancer cells underpins tumor progression and therapy resistance. However, the mechanism of epigenetic dysregulation that drives such divergence remains unclear. This study introduces integrated multimodal experimental platform specialized in analyzing inter/intraclonal heterogeneity (IMPACH), a scalable platform that integrates lineage tracing, genetic perturbat...

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Literature Corpus work
e3da5b33-f9dd-5f8e-be3d-78b43f5b268d
DOI
10.1101/2025.05.24.655549
Open publication

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Clonal lineage tracing and parallel multiomics profiling reveal transcriptional diversification induced by ARID1A deficiencyDOI 10.1101/2025.05.24.655549
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