Article

Genetic and epigenetic driven variation in regulatory regions activity contribute to adaptation and evolution under endocrine treatment

2022-02-18

Abstract excerpt

Comprehensive profiling of hormone-dependent breast cancer (HDBC) has identified hundreds of protein-coding alterations contributing to cancer initiation 1, 2 , but only a handful have been linked to endocrine therapy resistance, potentially contributing to 40% of relapses 1, 3–9 . If other mechanisms underlie the evolution of HDBC under adjuvant therapy is currently unknown. In this work, we employ integrative...

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Literature Corpus work: 02ebf2ba-6e0a-55cd-bdf1-1aee55cd276e
DOI: 10.1101/2022.02.15.480537

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