Article
Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations.
Cancer cell - 12 Feb 2018
Jeselsohn Rinath, Bergholz Johann S, Pun Matthew, Cornwell MacIntosh, Liu Weihan, Nardone Agostina, Xiao Tengfei, Li Wei, Qiu Xintao, Buchwalter Gilles, Feiglin Ariel, Abell-Hart Kayley, Fei Teng, Rao Prakash, Long Henry, Kwiatkowski Nicholas, Zhang Tinghu, Gray Nathanael, Melchers Diane, Houtman Rene, Liu X Shirley, Cohen Ofir, Wagle Nikhil, Winer Eric P, Zhao Jean, Brown Myles
Abstract excerpt
Estrogen receptor α (ER) ligand-binding domain (LBD) mutations are found in a substantial number of endocrine treatment-resistant metastatic ER-positive (ER+) breast cancers. We investigated the chromatin recruitment, transcriptional network, and genetic vulnerabilities in breast cancer models harboring the clinically relevant ER mutations. These mutants exhibit both ligand-independent functions that mimic...
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