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GRHL2 motif is associated with intratumor heterogeneity of cis-regulatory elements in luminal breast cancer

8 Jun 2022

Abstract excerpt

Abstract In breast cancer patients, tumor heterogeneity is associated with prognosis and therapeutic response; however, the epigenetic diversity that exists in primary tumors remains unknown. Using a single-cell sequencing assay for transposase-accessible chromatin (scATAC-seq), we obtained the chromatin accessibility profiles of 12,452 cells from 16 breast cancer patients including 11 luminal, 1 luminal-HER2, 1...

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PMID: 35676392
DOI: 10.1038/s41523-022-00438-6

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