Article

Epigenetic changes with age primes mammary luminal epithelia for cancer initiation

2021-02-13

Abstract excerpt

<h4>Summary</h4> Aging causes molecular changes that manifest as stereotypical phenotypes yet aging-associated diseases progress only in certain individuals. At lineage-specific resolution, we show how stereotyped and variant responses are integrated in mammary epithelia. Age-dependent directional changes in gene expression and DNA methylation (DNAm) occurred almost exclusively in luminal cells and implicated gen...

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Literature Corpus work: 5dce9eaf-04fa-5f4e-8964-a025fce20f3f
DOI: 10.1101/2021.02.12.430777

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