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Article

Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.

Nature - 1 Jun 2018

Chen Michael C, Tippana Ramreddy, Demeshkina Natalia A, Murat Pierre, Balasubramanian Shankar, Myong Sua, Ferré-D'Amaré Adrian R

Abstract excerpt

Guanine-rich nucleic acid sequences challenge the replication, transcription, and translation machinery by spontaneously folding into G-quadruplexes, the unfolding of which requires forces greater than most polymerases can exert1,2. Eukaryotic cells contain numerous helicases that can unfold G-quadruplexes 3 . The molecular basis of the recognition and unfolding of G-quadruplexes by helicases remains poorly...

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Identifiers

PMID: 29899445
DOI: 10.1038/s41586-018-0209-9
PMCID: PMC6261253

Genes

DHX36

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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