Cryo-EM structures of human FANCJ reveal the mechanism of G-quadruplex unwinding and disease-associated mutations.

Abstract excerpt

Guanine-rich nucleic acid sequences can fold into G-quadruplex (G4) structures that regulate DNA replication, transcription, and translation. Fanconi anemia group J helicase (FANCJ) resolves G4 structures at stalled replication forks. Despite its central role in genome maintenance, the molecular basis of G4 recognition and unwinding by FANCJ has remained unclear. Here, we report cryo-EM structures of human FANCJ...

Topics

Join the communities discussing this publication.

• Adenosine Triphosphate
• Basic-Leucine Zipper Transcription Factors
• Cryoelectron Microscopy
• DNA Helicases
• DNA, Single-Stranded