Article

Specificity of the stabilising interaction between intrinsically disordered protein sequences and G-quadruplexes in RNA

2025-10-20

Abstract excerpt

<h4>ABSTRACT</h4> Intrinsically disordered regions (IDRs) are present in and essential for the function of nearly all the proteins involved in the regulation, cell and developmental processes. The RGG domain in IDRs binds ‘promiscuously’ to RNA G-quadruplexes (rG4s), a non-canonical 4-stranded secondary structure that occurs in many transcripts involved in gene regulation. Here we show, using weak binding interac...

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Literature Corpus work: 05a04c6d-c4e4-54cd-9dcb-d0d061169b86
DOI: 10.1101/2025.10.19.683336

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