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Article

G-register exchange dynamics in guanine quadruplexes.

Nucleic acids research - 5 May 2016

Harkness Robert W, Mittermaier Anthony K

Abstract excerpt

G-quadruplexes (GQs) are 4-stranded DNA structures formed by tracts of stacked, Hoogsteen-hydrogen bonded guanosines. GQs are found in gene promoters and telomeres where they regulate gene transcription and telomere elongation. Though GQ structures are well-characterized, many aspects of their conformational dynamics are poorly understood. For example, when there are surplus guanosines in some of the tracts, they...

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Identifiers

PMID: 27060139
DOI: 10.1093/nar/gkw190
PMCID: PMC4856995

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Source receipt: pubmed, retrieved 7 Sept 2026.

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