Article

The RNA helicase DHX36/G4R1 modulates <i>C9orf72</i> GGGGCC repeat-associated translation

2021-04-26

Abstract excerpt

<h4>ABSTRACT</h4> GGGGCC (G 4 C 2 ) hexanucleotide repeat expansions (HRE) in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat-associated non-AUG (RAN) translation of this expansion generates toxic proteins that accumulate in patient brains and contribute to disease pathogenesis. The DEAH-Box Helicase 36 (DHX36/G4R1) plays active roles i...

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Literature Corpus work: 2165bfe2-35e1-5f80-a170-fb3ac9677c83
DOI: 10.1101/2021.04.25.441260

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