Article

Single-molecule analysis of the improved variants of the G-quadruplex recognition protein G4P

2023-05-09

Abstract excerpt

As many as 700,000 unique sequences in the human genome are predicted to fold into G-quadruplexes (G4s), non-canonical structures formed by Hoogsteen guanine-guanine pairing within G-rich nucleic acids. G4s play both physiological and pathological roles in many vital cellular processes including DNA replication, DNA repair and RNA transcription. Several reagents have been developed to visualize G4s in vitro and i...

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Literature Corpus work: 33e86b21-4c32-55d0-97b8-ff33464c0c2f
DOI: 10.1101/2023.05.08.539902

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