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Article

Conferring substrate specificity to DNA helicases: role of the RecQ HRDC domain.

Structure (London, England : 1993) - 1 Aug 2005

Bernstein Douglas A, Keck James L

Abstract excerpt

RecQ DNA helicases are multidomain enzymes that play pivotal roles in genome maintenance pathways. While the ATPase and helicase activities of these enzymes can be attributed to the conserved catalytic core domain, the role of the Helicase-and-RNase-D-C-terminal (HRDC) domain in RecQ function has yet to be elucidated. Here, we report the crystal structure of the E. coli RecQ HRDC domain, revealing a globular fold...

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Share to Conserved Sequence
Share to Crystallography, X-Ray
Share to DNA, Single-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

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Share to RecQ Helicases

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Source

Identifiers

PMID: 16084389
DOI: 10.1016/j.str.2005.04.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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