Article
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.
Nucleic acids research - 26 May 2015
Newman Joseph A, Savitsky Pavel, Allerston Charles K, Bizard Anna H, Özer Özgün, Sarlós Kata, Liu Ying, Pardon Els, Steyaert Jan, Hickson Ian D, Gileadi Opher
Abstract excerpt
Bloom's syndrome helicase (BLM) is a member of the RecQ family of DNA helicases, which play key roles in the maintenance of genome integrity in all organism groups. We describe crystal structures of the BLM helicase domain in complex with DNA and with an antibody fragment, as well as SAXS and domain association studies in solution. We show an unexpected nucleotide-dependent interaction of the core helicase domain...
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