Article

Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless

2022-11-11

Abstract excerpt

<h4>Summary</h4> Unwinding RNA secondary structures by RNA helicases is essential for RNA metabolism. How the basic unwinding reaction of DExH-type helicases is regulated by their accessory domains is unresolved. Here, we combine structural and functional analyses to address this challenge for the prototypic DExH RNA helicase maleless (MLE) from Drosophila . We captured the helicase cycle of MLE with multiple s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9158dd0-65fd-5aca-ac38-199e386dd44b
DOI: 10.1101/2022.11.11.516098

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase malelessDOI 10.1101/2022.11.11.516098Read

ATP-dependent roX RNA remodeling by the helicase maleless enables specific association of MSL proteins.Semantic proximity Read

Structure-function analysis of the RNA helicase maleless.Semantic proximity Read

A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila.Semantic proximity Read

Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila.Semantic proximity Read

Trypanosome RNA helicase KREH2 differentially controls non-canonical editing and putative repressive structure via a novel proposed ‘bifunctional’ gRNA in mRNA A6Semantic proximity Read

Deadenylation and Decapping Factors Cooperatively Stimulate Biochemical Activities of DEAD-Box ATPase Dhh1Semantic proximity Read

DDX RNA helicases: key players in cellular homeostasis and innate antiviral immunitySemantic proximity Read

DHX9 helicase promotes R-loop formation in cells with impaired RNA splicingSemantic proximity Read

Structure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domain.Semantic proximity Read

Mutational analysis of the functional motifs of the DEAD-box RNA helicase Me31B/DDX6 in Drosophila germline development.Semantic proximity Read

Specific catalytically impaired DDX3X mutants form sexually dimorphic hollow condensates.Semantic proximity Read

The human Dicer helicase domain mediates ATP hydrolysis and RNA rearrangementSemantic proximity Read