Article
Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA.
Acta crystallographica. Section D, Biological crystallography - 1 May 2014
Swan Michael K, Legris Valerie, Tanner Adam, Reaper Philip M, Vial Sarah, Bordas Rebecca, Pollard John R, Charlton Peter A, Golec Julian M C, Bertrand Jay A
Abstract excerpt
Bloom's syndrome is an autosomal recessive genome-instability disorder associated with a predisposition to cancer, premature aging and developmental abnormalities. It is caused by mutations that inactivate the DNA helicase activity of the BLM protein or nullify protein expression. The BLM helicase has been implicated in the alternative lengthening of telomeres (ALT) pathway, which is essential for the limitless...
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