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Article

A prominent -hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation

8 Nov 2010

Abstract excerpt

RecQ helicases have attracted considerable interest in recent years due to their role in the suppression of genome instability and human diseases. These atypical helicases exert their function by resolving a number of highly specific DNA structures. The crystal structure of a truncated catalytic core of the human RECQ1 helicase (RECQ1(49-616)) shows a prominent β-hairpin, with an aromatic residue (Y564) at the...

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PMID: 21059676
DOI: 10.1093/nar/gkq1031

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