Article

Loss of DHX36/G4R1, a G4 resolvase, drives genome instability and regulates innate immune gene expression in cancer cells

2025-01-03

Abstract excerpt

<h4>SUMMARY</h4> G-quadruplexes (G4s) are four-stranded alternative secondary structures formed by guanine-rich nucleic acids and are prevalent across the human genome. G4s are enzymatically resolved using specialized helicases. Previous in vitro studies showed that DEAH-box Helicase 36 (DHX36/G4R1/RHAU), has the highest specificity and affinity for G4 structures. Here, by mapping genome-wide DNA double-strand b...

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Literature Corpus work: ee284f67-6567-56db-b79b-7badb076230f
DOI: 10.1101/2025.01.03.631217

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