Article

Differential local stability governs the metamorphic fold-switch of bacterial virulence factor RfaH

2019-05-08

Abstract excerpt

A regulatory factor RfaH, present in many Gram-negative bacterial pathogens, is required for transcription and translation of long operons encoding virulence determinants. Escherichia coli RfaH action is controlled by a unique large-scale structural rearrangement triggered by recruitment to transcription elongation complexes through a specific DNA sequence within these operons. Upon recruitment, the C-terminal do...

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Literature Corpus work: 5c57c524-1901-5c24-a971-0ae0c8c156fd
DOI: 10.1101/629477

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