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Transient transcription factor (OSKM) expression is key towards clinical translation of in vivo cell reprogramming

28 Apr 2017

Abstract excerpt

Abstract Reprogramming adult, fully differentiated cells to pluripotency in vivo via Oct3/4 , Sox2 , Klf4 and c‐Myc (OSKM) overexpression has proved feasible in various independent studies and could be used to induce tissue regeneration owing to the proliferative capacity and differentiation potential of the reprogrammed cells. However, a number of these reports have described the generation of teratomas caused...

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PMID: 28455313
DOI: 10.15252/emmm.201707650

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