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Comparative analysis of mouse strains for <i>in vivo</i> reprogramming

2024-03-08

Abstract excerpt

<h4>Summary</h4> In vivo reprogramming through the forced expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) has demonstrated great potential for reversing age-associated phenotypes, as the combination of these transcription factors actively promote cell regeneration and rejuvenation in various tissues and organs. However, continuous in vivo OSKM expression raised safety concerns due to loss of cell identity, decr...

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Literature Corpus work
d7eb5f98-a6fe-53f6-8fa7-d7d8452fdd9f
DOI
10.1101/2024.03.08.584074
Open publication

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Comparative analysis of mouse strains for <i>in vivo</i> reprogrammingDOI 10.1101/2024.03.08.584074
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